![]() ![]() If patients take too much Coumadin, they can bleed uncontrollably, but if they take too little of the blood thinner, they run the risk of developing blood clots. ![]() Coumadin, also known by its generic name warfarin, is commonly prescribed to nursing home patients and must be carefully monitored by health care providers. The Washington Post recently highlighted problems with the blood thinner Coumadin on its front page. All rights reserved.Medical errors involving blood thinner Coumadin (warfarin) widespreadįailure to adequately monitor the effects of the blood-thinning drug Coumadin can cause serious and even fatal injuries. Copyright © 2021 Wolters Kluwer Health, Inc. Initial INRs and reported quantity ingested may be useful to predict those needing treatment. Peak INR values after warfarin overdose occur between 24 and 36 hours after presentation. 3.4), although the bleeding rate was similar. Peak INR was greater in the AOC than the acute overdose group (6.1 vs. Factors associated with an INR > 10 included initial INR and reported quantity ingested. The AOC group had a greater mean age (56 vs. The median warfarin dose ingested was 75 mg. ![]() Most patients received phytonadione (62.0%), with fewer receiving blood products (16.6%). The median time to phytonadione was 22.0 hours. In patients who did not receive reversal therapies, INR peaked at a median value of 3.8 (interquartile range 2.6–5.5) between 24 and 36 hours. ![]() A total of 163 overdoses were included, 68 acute and 95 AOC. Secondary outcomes included risk factors associated with INR >10 and describing patient characteristics. The primary outcome was to determine the time after presentation to peak INR. This is a retrospective cohort study for all acute and acute-on-chronic (AOC) warfarin overdoses reported to the Maryland Poison Center in patients ≥12 years between January 1st, 2000, until October 31st, 2019, managed in a health care facility. However, there is a paucity of the literature relating to an acute overdose of warfarin. Guidelines exist on the management of supratherapeutic/subtherapeutic international normalized ratio (INR) values for patients on warfarin. ![]()
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